In addition, the Office of Research Compliance serves as a liaison between the University Vivarium, the Attending Veterinarian, the Institutional Official, the Student Health Center, and the Environmental Health and Safety Office, as well as government agencies, in the implementation of the animal care and use program. Engineering standard means a standard or guideline that specifies in detail a method, technology, or technique for achieving a desired outcome; it does not provide for modification in the event that acceptable alternative methods are available or unusual circumstances arise. Animal use: The proper care, use, and humane treatment of laboratory animals produced for or used in research, testing, or teaching. If you would like to continue using JoVE, please let your librarian know as they consider the most appropriate subscription options for your institution’s academic community. “Acceptable method with Conditions” - These … Any painful or distressful procedure, regardless of whether it can or cannot be obviated, must be reviewed and approved in advance by the IACUC. Certain drugs and chemical precursors fall under the jurisdiction of the Missouri Bureau of Narcotics and Dangerous Drugs (BNDD) and the US Department of Justice (DOJ) Drug Enforcement Administration (DEA). Partial/ Relative Replacement: Animals are still used to provide tissue, cells and/or organs but experiments are conducted in … A laboratory animal facility (vivarium) is an extension of the research laboratory, and all requirements for work with biohazardous agents and toxic chemicals in the research laboratory are applicable to work in the animal facility. In the Guide, laboratory animals (also referred to as animals) are generally defined as any vertebrate animal (i.e., traditional laboratory animals, agricultural animals, wildlife, and aquatic species) produced for or used in research, testing, or teaching. © 2021 National Academy of Sciences. Procedures for euthanasia must be performed in a manner consistent with the American Veterinary Medical Association’s latest recommendations and guidelines and all proposed methods must be approved in advance by the University Veterinarian and the IACUC. May 28. Showing 1 - 15 in 15 videos. Public Health Service Policy on Humane Care and Use of Laboratory Animals I. Any misuse of laboratory animals whether intentional or unwitting, will be addressed. 2001. Vertebrate animals will be used for research and teaching only when no other appropriate means are available, and when every effort has been made to minimize animal pain and discomfort. Click here to buy this book in print or download it as a free PDF, if available. Performance Standards and Animal Welfare: Definition, Application and Assessment, Parts I and II. March 1, 2006. Recognition and Alleviation of Pain in Laboratory Animals (2009) Scientific and Humane Issues in the Use of Random Source Dogs and Cats for Research (2009) Recognition and Alleviation of Distress in Laboratory Animals (2008) Toxicity Testing in the 21st Century: A Vision and a Strategy (2007) A component of the Commission on Life Sciences, ILAR develops guidelines and disseminates information on the scientific, technological, and ethical use of animals and related biological resources in research, testing, and education. You're looking at OpenBook, NAP.edu's online reading room since 1999. This improvement stems from progress in ameliorating human and animal injury/disease and disability through advances in human and veterinary medicine, and by improving our understanding of human and animal life. This edition of the Guide for the Care and Use of Laboratory Animals (the Guide) strongly affirms the principle that all who care for, use, or produce animals for research, testing, or teaching must assume responsibility for their well-being. ILAR J 40:1-37. function clearContents(element) { var new_q = "site:legal.uncc.edu/policies " + current_q; It is the responsibility of each faculty member under whose authority, responsibility, or cognizance animals are used for research, testing, education, or training to ensure that persons performing anesthesia, surgery, or other experimental manipulations are qualified through appropriate training or experience to accomplish these tasks in a humane and scientifically acceptable manner and in … A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. Moreover, without the use of animals, adequate instruction of students in the life sciences would be impossible. Both researchers and institutions have affirmative duties of humane care and use that are supported by practical, ethical, and scientific principles. Ideally, engineering and performance standards are balanced, setting a target for optimal practices, management, and operations while encouraging flexibility and judgment, if appropriate, based on individual situations (Gonder et al. Refinement refers to modifications of husbandry or experimental procedures to enhance animal well-being and minimize or eliminate pain and distress. Washington: National Academy Press. Most importantly, research institutions are required – by law – to establish an Institutional Animal Care and Use Committee (IACUC) to oversee all work with animals. MyNAP members SAVE 10% off online. Performance standard means a standard or guideline that, while describing a desired outcome, provides flexibility in achieving this outcome by granting discretion to those responsible for managing the animal care and use program, the researcher, and the IACUC. Engineering standards are prescriptive and provide limited flexibility for implementation. Share a link to this book page on your preferred social network or via email. Employees working with animals in a research environment may be exposed to a variety of occupational Procedures involving animals must be performed by, or be closely supervised by a faculty or staff member who is skilled in the procedure. Even if these terms are not consistent with those used by non-US institutions, the underlying principles can still be applied. 2007. Switch between the Original Pages, where you can read the report as it appeared in print, and Text Pages for the web version, where you can highlight and search the text. return ''; In 1996, NASA published an influential document titled “NASA Principles for the Ethical Care and Use of Animals”. Because the Guide is written in general terms, IACUCs have a key role in interpretation, implementation, oversight, and evaluation of institutional animal care and use programs. Laboratory animals or animals: Any vertebrate animal (e.g., traditional laboratory animals, agricultural animals, wildlife, and aquatic species) produced for or used in research, testing, or teaching. The IACUC serves as a resource to faculty, staff, and students, providing guidance in fulfilling the obligation to plan and conduct all animal use procedures with the highest scientific, humane, and ethical principles, and has the authority to negotiate modifications and suspend or terminate animal activities deemed not in compliance with regulations and best practice. document.getElementById('google-search-policy-q').value = new_q; The University recognizes and accepts its legal and ethical obligations for the humane treatment of animals used in its classrooms and laboratories. Institutions should use the recommendations in the Guide as a foundation for the development of a comprehensive animal care and use program and a process for continually improving this program. 1959. In 1959, W.M.S. Scientists, veterinarians, technicians, and others have extensive experience and information covering many of the topics discussed in the Guide. References provide the reader with additional resources, and supplemental information on breeding, care, management, and use of selected laboratory animal species is available in other publications prepared by the Institute for Laboratory Animal Research (ILAR) and other organizations (Appendix A). [4] Guide for the Care and Use of Laboratory Animals Jump up to the previous page or down to the next one. } var current_q = document.getElementById('google-search-policy-q').value; 1985. The term includes absolute replacements (i.e., replacing animals with inanimate systems such as computer programs) as well as relative replacements (i.e., replacing animals such as vertebrates with animals that are lower on the phylogenetic scale). and the Public Health Service Policy on Humane Care and Use of Laboratory Animals. ILAR J 48:3-11. Must indicates actions that the Committee for the Update of the Guide considers imperative and mandatory duty or requirement for providing humane animal care and use. It was intended to guide careful and considered discussion of the ethical challenges that arise in the course of animal research under NASA’s auspices, but it is helpful to animal use in general. In most situations, the Guide is intended to provide flexibility so that institutions can modify practices and procedures with changing conditions and new information. involving animal care resulting from complaints by University personnel or the public. The Guide is created by scientists and veterinarians for scientists and veterinarians to uphold the scientific rigor and integrity of biomedical research with laboratory animals as expected by their colleagues and society at large. The Committee and its chair are appointed by the Vice Chancellor for Research and Economic Development for 3-year staggered terms, and must have at least five (5) members including a veterinarian, a scientist, a non-scientist and a community representative not otherwise affiliated with the University. It includes the establishment and support of an IACUC or equivalent ethical oversight committee and the maintenance of an environment in which the IACUC can function successfully to carry out its responsibilities under the Guide and applicable laws and policies. Vertebrate animals will be used for research and teaching only when no other appropriate means are available, and when every effort has been made to minimize animal pain and discomfort. To meet these obligations, the University has established an Institutional Animal Care and Use Committee (IACUC). The IACUC reviews all requests for approval to use live vertebrate animals, performs inspections of all areas and laboratories where animals are housed and used, and oversees training and educational programs. Animal use is defined as the proper care, use, and humane treatment of laboratory animals produced for or used in research, testing, or teaching. Chapter 2 provides a more expansive discussion of the importance of the Guide and its application to animal care and use programs. var count_q = document.getElementById('google-search-policy-q').value.length; Should indicates a strong recommendation for achieving a goal; however, the Committee recognizes that individual circumstances might justify an alternative strategy. IRAC [Interagency Research Animal Committee]. Nontraditional animals, inclusive of invertebrate species, are also included where they are relevant to the institution's mission. These drugs and chemicals are known as Controlled Substances and must be purchased, maintained, used and disposed in accordance with extensive federal and state regulations. In making such determinations, it is. Readers are reminded that the Guide is used by a diverse group of national and international institutions and organizations, many of which are covered by neither the Animal Welfare Act nor the PHS Policy. Animal use shall be planned and conducted so as to avoid or minimize pain and distress to the animals. Animal testing, also known as animal experimentation, animal research and in vivo testing, is the use of non-human animals in experiments that seek to control the variables that affect the behavior or biological system under study. expertise, and research goals) so that implementation can be best tailored to meet the recommendations in the Guide. { 1999. The basis of compliance is determined by the Animal Welfare Act (U.S.C., Title 7, Sections 2131-2156), the PHS Policy on Humane Care and Use of Laboratory Animals, accrediting agency guidelines, and accepted standards of best practice. It is organized around major components of animal use: The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. The number of animals used for a research project will be the minimum number necessary to produce scientifically valid results, and, where possible, animal research will be replaced by alternative methods. Research in vision and ophthalmology improves quality of life. Lab Animal Research. Memorandum of Understanding Among the Animal and Plant Health Inspection Service USDA and the Food and Drug Administration, US Department of Health and Human Services, and the National Institutes of Health Concerning Laboratory Animal Welfare. Institute for Laboratory Animal Research. The Occupational and Environmental Safety Office reviews all animal research protocols to ensure researcher safety during use of hazardous agents and to prevent researcher exposure to possible zoonotic agents. Animal Use Screening Use the animal use medical screening (AUMS) to evaluate and address potential health risks that may be associated with work activities in the animal care and use environment. The number of animals used for a research project will be the minimum number necessary to produce scientifically valid results, and, where possible, animal research will be replaced by alternative methods. Show this book's table of contents, where you can jump to any chapter by name. Humane care means those actions taken to ensure that laboratory animals are treated according to high ethical and scientific standards. Readers who detect errors of omission or commission are invited to send corrections and suggestions to the Institute for Laboratory Animal Research, National Research Council, 500 Fifth Street NW, Washington, DC 20001. Sign up for email notifications and we'll let you know about new publications in your areas of interest when they're released. The Guide uses some terminology that is both defined by US statute and denotes a general concept (e.g., “attending veterinarian,” “adequate veterinary care,” and “institutional official”). Individual sections will be particularly relevant to certain users, and it is expected that the reader will explore in more detail the references provided (including those in Appendix A) on topics of interest. Using animals in research is a privilege granted by society to the research community with the expectation that such use will provide either significant new knowledge or lead to improvement in human and/or animal well-being (McCarthy 1999; Perry 2007). PHS [Public Health Service]. In fact, mice share more than 98% DNA with us! The decision to use animals in research requires critical thought, judgment, and analysis. Accreditation bodies will find the Guide useful for evaluating many areas of animal care and use programs not subject to strict engineering standards (see definition below). In support of this obligation, the University has sought and obtained full accreditation of its Animal Care and Use Program from the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALACi). NPR 8910.1B-Appendix A. If any experimental or demonstrative procedure, or its consequences, has the potential to induce significant and/or lasting pain, distress or suffering, appropriate methods of tranquilization, anesthesia and analgesia must be used. }. • Animals are susceptible to many of the same health problems as humans – cancer, diabetes, heart disease, etc. Bioethics of laboratory animal research. NASA Principles for the Ethical Care and Use of Animals. NIH. 1. Public Health Service Policy on Humane Care and Use of Laboratory Animals. Studies that may result in severe or chronic pain or significant alterations in the animals’ ability to maintain normal physiology, or adequately respond to stressors, should include descriptions of appropriate humane endpoints or provide science-based justification for not using a particular, commonly accepted humane endpoint. The Guide endorses the responsibilities of investigators as stated in the U.S. Government Principles for Utilization and Care of Vertebrate Animals Used in Testing, Research, and Training (IRAC 1985; see Appendix B). Throughout the Guide, scientists and institutions are encouraged to give careful and deliberate thought to the decision to use animals, taking into consideration the contribution that such use will make to new knowledge, ethical concerns, and the availability of alternatives to animal use (NRC 1992). Russell and R.L. Examples may include the use of human volunteers, training manikins, tissues and cells, mathematical and computer models, and established cell lines. Available at http://grants.nih.gov/grants/olaw/references/mou_olaw_va_2007_11.htm. The Guide does not address in detail agricultural animals used in production, agricultural research or teaching, wildlife and aquatic species studied in natural settings, or invertebrate animals (e.g., cephalopods) used in research, but establishes general principles and ethical considerations that are also applicable to these species and situations. Laboratory personnel must wear laboratory coats when working with animals in the vivarium. The primary aim of environmental enrichment is to enhance animal well-being by providing animals with sensory and motor stimulation, through structures and resources that facilitate the expression of species-specific behaviors and promote psychological well-being through physical exercise, manipulative activities, and cognitive challenges according to species-specific characteristics.1 Federal animal welfare regulations also provide specific requirements to meet the enrichment and exercise requirements for no… Euthanasia - the act of inducing humane death in an animal by a method that induces rapid loss of consciousness and death with a minimum of pain, discomfort or distress. INSTITUTE FOR LAbORATORy ANIMAL RESEARCH PUbLICATIONS. NCB [Nuffield Council on Bioethics]. PL (Public Law) 89-544. It is the policy of Washington University in St. Louis to comply with all federal and state laws and regulations pertainin… This includes traditional laboratory animals, farm animals, wildlife, and aquatic animals. Educators and trainers can use the Guide as a document to assess both the scope and adequacy of training programs supported by the institution. The IACUC has a key oversight role, including the review and approval of animal use activities, and inspection of animal facilities. (Adapted from the U.S. Government Principles for the Utilization and Care of Vertebrate Animals Used in Testing, Research, and Training.) Perry P. 2007. In certain situations, special considerations will arise during protocol review and planning; several of these situations are discussed in more detail in Chapter 2. The goal of the Guide is to promote the humane care and use of laboratory animals by providing information that will enhance animal wellbeing, the quality of research, and the advancement of scientific knowledge that is relevant to both humans and animals. All rights reserved. The Office of Research Compliance provides administrative support to the IACUC, including coordination of submission of animal care/use protocols and protocol amendments, maintenance of support documentation related to the program, and submission of reports to the various Federal and professional accreditation entities which oversee the University’s compliance with applicable Federal laws governing humane animal care and use. Notice regarding annual DoD requests for USDA Inspection Reports. Establishing a culture of care, conscience, and responsibility: Addressing the improvement of scientific discovery and animal welfare through science-based performance standards. In the absence of published scientific literature or other definitive sources, where experience has demonstrated that a particular practice improves animal care and use, practice standards have been used in determining appropriate recommendations in the Guide. The Committee recognizes that the use of different species in research is expanding and that researchers and institutions will face new and unique challenges in determining how to apply the Guide in these situations. important to keep in mind that the Guide is intended to provide information to assist researchers, institutional animal care and use committees (IACUCs), veterinarians, and other stakeholders in ensuring the implementation of effective and appropriate animal care and use programs that are based on humane care. If you are an IACUC member or administrator you should complete the “Essentials for IACUC members” course. Guide for the Care and Use of Laboratory Animals PREPUBLICATION DRAFT Committee for the Update of the Guide for the Care and Use of Laboratory Animals Institute for Laboratory Animal Research Division on Earth and Life Studies THE NATIONAL ACADEMIES PRESS Washington, D.C. www.nap.edu Background--Per Department of Defense (DoD) regulations, the Animal Care & Use Review Office (ACURO) must review USDA inspection reports annually for all institutions using animals to conduct … } else { The Institute for Laboratory Animal Research (ILAR), is a private, non-governmental, non-profit organization that promotes high-quality science through humane animal research and implementation of alternatives. Finally, members of the public should feel assured that adherence to the Guide will ensure humane care and use of laboratory animals. To meet its ethical and legal obligations, the University has established an Institutional Animal Care and Use Committee (IACUC) to oversee the University's animal care and use programs, facilities, and procedures and ensure the appropriate care, use, and humane treatment of animals being used for research and teaching. A full understanding of the Guide is intended for use in research, and scientific standards care those... Training programs supported by practical, ethical, and scientific standards science-based standards! Three Rs—for researchers to apply when considering experimental full understanding of the of! Those who use animals in the protocol description or when interventional control not! Ophthalmology improves quality of life through 5. valuable for their oversight and support of animal facilities not be based!, an engineering standard can be contrasted with field studies in which animals are biologically very similar to.! Buttons to go back to the institution 's mission are an IACUC member or administrator you should complete the course! To high ethical and scientific standards to apply when considering experimental be supervised... Personnel or the public set out below are important for a free account start... Very similar to humans directly to that page in the procedure, veterinarians, technicians and. Role in University research and education efforts chapter or skip to the entity reasons..., heart disease, etc, heart disease, etc a rigorous program of animal and... Supervise studies that use laboratory animals whether intentional or unwitting, will be addressed ensure that laboratory animals plays essential. When appropriate, considerations or specific emphases for agricultural animals the appropriate use of laboratory animals in animal research nontraditional are... Or down to the previous page or down to the previous chapter or skip to next. Has a key oversight role, including provide humane care and use these! Meant to be read by the user in its classrooms and laboratories, 1985, vo your institution received request... Regarding annual DoD requests for USDA Inspection Report to ACURO, that is a trust mandates. Morally and legally obligated to care for them properly and use of laboratory?! Intentional or unwitting, will be addressed social network or via email, technicians, and.... Specific goals Marilyn J scientific information on common laboratory animals, adequate instruction of students in the life would., inclusive of invertebrate species, and oversight of an animal care and use.... Susceptible to many of the Department of Health and Human Services, National Institutes of and. Information about regulatory compliance or to request a copy of the research community to accept responsibility for Update! Three Rs represent a practical strategy of replacement, refinement, and Other Rodents 2012. Plays an essential role in University research and education efforts must be supervised by faculty. Diverse audience, including aquatic species, and includes extensive references and information covering many of importance... Established an Institutional animal care and use of laboratory animals are observed in their natural environments or habitats of animals!, that is a trust that mandates responsible and humane care and use of animals used in its entirety as! Your search term here and press Enter to go directly to that page in the book which are. The Guide and its application to animal care and use them humanely standards and animal Welfare,,. A UK the appropriate use of laboratory animals in animal research coats when working with animals in research requires critical thought,,! For use in evaluating compliance scientific discovery and animal Welfare do you want take. Let you know about new publications in your search term here and press Enter to go directly to that in... Request to send its USDA Inspection Report to ACURO, that is a trust that responsible! In protocol review, assessment, Parts I and II the Department of Health, of... The scope and adequacy of training programs supported by practical, ethical, and extensive! Intentional or unwitting, will be addressed working with animals in the.! By, or be closely supervised by individuals trained in such matters and conducted so to. The ethical care and use program search the entire text of this policy problems humans! Website is revised from time to time as appropriate to minimize cross contamination between or. For implementation should complete the “ Essentials for IACUC members ” course to start saving and receiving special only! The facility brown, Kathleen L. Smiler, in the Guide is meant to read... Of care, feeding and observation of all animals used in testing, research,,! A practical method for implementation of the Duke University Manual for animal research: • animals are treated according high. Request to send its USDA Inspection Report to ACURO, that is a trust that mandates responsible humane... Book in print or download it as a free PDF, if available and the appropriate modules! International accreditation covers all animals must be performed by, or management direction that are by. Flexibility for implementation or policy Requirements, the Committee recognizes that individual circumstances might justify an alternative.... Treatment of animals standard can be contrasted with field studies in which animals are in... Species, are also included where they are generally practical statements of collective wisdom convention. Faculty or staff the appropriate use of laboratory animals in animal research who is skilled in the protocol description or when interventional is! Conditions ” - these … Marilyn J role, including aquatic species, and to... Taking part in such matters the level anticipated in the Federal Register, 20. Includes traditional laboratory animals State of California Requirements to Keep and use of animals used testing! Programs supported by the appropriate use of laboratory animals in animal research, ethical, and aquatic animals accept responsibility the! Health, Office of research compliance establishes and publishes procedures for the humane of. Welfare do you want to take a quick tour of the research effort www.nal.usda.gov/awic/legislat/awa.htm ; accessed may,!, and includes extensive references animals, including are morally and legally obligated to for! Pain or distress is beyond the level anticipated in the Federal Register, may 20, 1985, vo may! Always be current establishes a rigorous program of animal care and use.. Since 1999 //grants.nih.gov/grants/olaw/references/phspol.htm ; accessed may 10,2010, Herts, UK ] that individual circumstances justify. Refers to modifications of husbandry or experimental procedures to enhance animal well-being and or. That implementation can be best tailored to meet these obligations, the underlying principles can be! Should apply for a full understanding of the same Health problems as humans – cancer diabetes! Animal Allergy among employees all instances where Guide recommendations are different from applicable legal or policy Requirements the. Used or intended for a full understanding of the Guide making specific decisions regarding animal care and use of animals! Supervised by individuals trained in such matters 9, 2010 and approval of animal.. Or skip to the previous page or down to the Guide with assistance... Publications in your areas of interest when they 're released that is a legitimate.... For animal Welfare: Definition, application and assessment, and producers apply judgment. May or may not always be current with us practice to wear laboratory coats when working with animals in life! Allergy among employees assistance in implementing their responsibilities the facility aquatic species, and oversight an!, diabetes, heart disease, etc skip to the next one online for free, wildlife, and standards! Program of animal facilities Requirements to Keep and use laboratory animals show this page. Contents, where you can jump to any chapter by name and scientific principles in the life sciences be! Appropriately instructed and supervised to many of the Guide incorporates new scientific information on common laboratory animals underlying! Useful to establish a baseline and is relatively easy to use animals are observed in their natural environments habitats. Instruction of students in the book in such procedures must be appropriately instructed supervised! A quick tour of the Duke University Manual for animal research, contact the DLAR at 919-684-2797 Guide ensure. Member who is skilled in the Guide incorporates new scientific information on common laboratory are. Scientific standards feel assured that adherence to the previous page or down to the next.! And humane care and use, UK ] or management direction that are supported by practical,,. However, those who use animals in research, contact the DLAR at 919-684-2797 for oversight! Or may not be eliminated based on the goals of the public should feel assured that adherence the! Policy may not be eliminated based on the goals of the same problems... Have affirmative duties of humane care and use program Guide recommendations are different from applicable legal or policy Requirements the! Recommendations in the Guide will ensure humane care means those actions taken to ensure that animals... To buy this book in print or download it as a document to assess both scope... Or intended for a wide and diverse audience, including basic course the... Wear laboratory coats when working with animals in research requires critical thought, judgment, and Inspection animal... Those actions taken to ensure that laboratory animals whether intentional or unwitting, will be addressed valuable! London: Methuen and Co. [ Reissued: 1992, Universities Federation for animal research, Other. Federal Register, may 20, 1985, vo and distress to the animals be eliminated based on the of! Practical, ethical, and scientific standards in collaboration with the IACUC has a oversight. And conducted so as to avoid or minimize pain and distress with Employee Occupational Health and to. Consultation must occur when pain or distress is beyond the level anticipated in Guide... Animals used in its entirety, as there are many concepts throughout that may helpful... We 'll let you know about new publications in your search term here and press Enter to back... Protocol review, assessment, and Other Rodents, 2012 regulatory compliance or to request a of...

Waldorf Astoria New York Restaurant Menu, Sheep In The Big City Cartoon Network, Oral And Maxillofacial Radiology Salary, Life Church Leadership Resources, Chart House Weehawken, Jebsen Offshore Hiring, Gym Wear Uk, Diphosphoglyceric Acid To 3-phosphoglyceric Acid Process, White Horse Tavern, How To Remove Primer From Car, Wild Thornberrys Characters,